Sustainable Laser Therapy: A Modern Approach to Improving Regenerative Wound Healing that Employs Integrated, Low-Energy Systems

Abstract

Infrared biomodulation (PBM) is considered one of the most innovative solutions in modern regenerative medicine. This systematic review evaluates the available scientific evidence on the clinical efficacy and safety of combining three different infrared laser wavelengths (655, 850, and 905 nm) to accelerate the healing of acute and chronic wounds, as well as to treat human papillomavirus (HPV) warts. The search was conducted in reputable medical databases, including PubMed, Embase, the Cochrane Library, and Scopus, between 2020 and 2025, focusing on trials and systematic reviews.

The analysis of this data indicates that these three wavelengths constitute a comprehensive and integrated treatment regimen. The 655 nm wavelength targets the superficial layers of tissue, while the 850 nm wavelength targets the intermediate layers. The ultra-pulsed gallium arsenide (GaAs) laser at 905 nm penetrates deep structural tissues without causing thermal damage. This multi-wavelength approach demonstrated significant improvements in tissue regeneration indicators, enhanced collagen synthesis, a substantial reduction in inflammatory pathways, and a safer alternative for wart removal with fewer side effects compared to traditional non-specific methods such as Nd:YAG ablation or cryotherapy. The review concludes that this optical framework represents a sustainable and environmentally friendly treatment option, emphasizing that the current clinical challenge lies in standardizing accurate dosing protocols to encompass most cases.